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Mouse Anti-Human Monoclonal Antibody
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Application 
| FC |
|---|---|
| Primary Accession | P13987 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Clone Names | MEM-43/5 |
| Calculated MW | 14177 Da |
| Purification | Purified IgG prepared by affinity chromatography on Protein A |
|---|---|
| Shelf Life | 18 months from date of despatch. |
| Gene ID | 966 |
| Other Names | CD59 glycoprotein, 1F5 antigen, 20 kDa homologous restriction factor, HRF-20, HRF20, MAC-inhibitory protein, MAC-IP, MEM43 antigen, Membrane attack complex inhibition factor, MACIF, Membrane inhibitor of reactive lysis, MIRL, Protectin, CD59, CD59, MIC11, MIN1, MIN2, MIN3, MSK21 |
| Target/Specificity | Mouse anti-Human CD59 antibody, clone MEM-43/5 reacts with a PI-linked glycoprotein, Mw 18-20kDa found on all types of leucocytes including platelets. The antigen is expressed on many haemopoietic and non-haemopoietic cells. Mouse anti-Human CD59 antibody, clone MEM-43/5 recognizes an epitope distinct to that bound by clone MEM-43. |
| Preservative & Stabilisers | 0.09% Sodium azide; Stabilising agent |
| Storage | Storage at +4ºC. DO NOT FREEZE. |
| Precautions | Anti-Human CD59 Antibody, clone MEM-43/5 (RPE) is for research use only and not for use in diagnostic or therapeutic procedures. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
1. Stefanova, I. et al. (1989) Characterization of a broadly expressed human leucocyte surface antigen MEM-43 anchored in membrane through phosphatidylinositolMol. Immunol. 26: 153-161. 1. Stefanova, I., et al. (1989) in Leucocyte Typing IV: White cell differentiation antigens.Ed. Knapp, W. et al. Oxford University Press pp 678-697. 3. Tandon, N. et al. (1994) Expression and function of multiple regulators of complement activation in autoimmune thyroid disease.Immunology 81: 643-647. 4. Horejsi, V. et al. (1988) Monoclonal antibodies against human leucocyte antigens. II. Antibodies against CD45 (T200), CD3 (T3), CD43, CD10 (CALLA), transferrin receptor (T9), a novel broadly expressed 18-kDa antigen (MEM-43) and a novel antigen of restricted expression (MEM-74).Fol. Bio. (Prague) 34: 23-24. 5. Ellison, B.S. et al. (2007) Complement susceptibility in glutamine deprived breast cancer cells.Cell Div. 2: 20. 6. Vanderplasschen, A. et al. (1998) Extracellular enveloped vaccinia virus is resistant to complement because of incorporation of host complement control proteins into its envelope.Proc Natl Acad Sci U S A. 95: 7544-9. 7. Takemoto, M. et al. (2007) Human herpesvirus 7 infection increases the expression levels of CD46 and CD59 in target cells.J Gen Virol. 88: 1415-22. 8. Ohyama, M. et al. (2006) Characterization and isolation of stem cell-enriched human hair follicle bulge cells.J Clin Invest. 116: 249-60.
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