|Application ||IHC-F, FC, IP|
|Calculated MW||61128 Da|
|Purification||Purified IgG from ascites prepared by precipitation and ion exchange chromatography.|
|Shelf Life||18 months from date of despatch.|
|Other Names||B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4, Differentiation antigen CD19, T-cell surface antigen Leu-12, CD19, CD19|
|Target/Specificity||Mouse anti-Human CD19 antibody, clone LT19 recognizes human CD19 also known as T-cell surface antigen Leu-12 or B-lymphocyte surface antigen B4. CD19 is a ~95 kDa type I single pass transmembrane glycoprotein expressed on follicular dendritic cells and B-cells during maturation but is lost on development into plasma cells (de Rie et al.1989).CD19 is the broadest lineage specific marker for B cells and functions as a B-cell co-receptor in conjunction with CD21(Bradburyet al.1992),CD9,CD81andCD82(Horváthet al.1998). CD19 is implicated in the down-regulation of B cell growth and proliferation (Pezzuttoet al.1987).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD19 Antibody, clone LT19 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Hughes, G.J. et al. (2007) Virus immunocapture provides evidence of CD8 lymphocyte-derived HIV-1 in vivo.AIDS. 21: 1507-13. 2. Allen, J.S. et al. (2009) Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune complex capture.Diabetes. 58: 138-45. 3. McIntosh, K. et al. (2006) The immunogenicity of human adipose-derived cells: temporal changes in vitro.Stem Cells. 24: 1246-53. 4. Sengstake, S. et al. (2006) CD21 and CD62L shedding are both inducible via P2X7Rs.Int Immunol. 18 (7): 1171-8. 5. Villarroel Dorrego, M. et al. (2006) Transfection of CD40 in a human oral squamous cell carcinoma keratinocyte line upregulates immune potency and costimulatory molecules.Br J Dermatol. 154: 231-8. 6. Franz, B. et al.(2011)Ex vivo characterization and isolation of rare memory B cells with antigen tetramers.Blood. 118: 348-57. 7. Lacal, P.M. et al. (2013) Glucocorticoid-induced tumor necrosis factor receptor family-related ligand triggering upregulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 and promotes leukocyte adhesion.J Pharmacol Exp Ther. 347: 164-72. 8. Franz, B. et al. (2011) Ex vivo characterization and isolation of rare memory B cells with antigen tetramers.Blood. 118: 348-57. 9. Girbl, T. et al. (2013) CD40-mediated activation of chronic lymphocytic leukemia cells promotes their CD44-dependent adhesion to hyaluronan and restricts CCL21-induced motility.Cancer Res. 73: 561-70. 10. Hertzberg, L. et al. (2010) Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group.Blood. 115: 1006-17. 11. Kakko, T. et al. (2011) Inflammatory effects of blood leukocytes: association with vascular function in neuropeptide Y proline 7-genotyped type 2 diabetes patients.Diab Vasc Dis Res. 8: 221-8. 12. Dorvignit, D. et al. (2012) Expression and biological characterization of an anti-CD20 biosimilar candidate antibody: a case study.MAbs. 4 (4): 488-96. 13. Karlsen M et al. (2015) TLR-7 and -9 stimulation of peripheral blood B cells indicate altered TLR signaling in primary Sjögren's syndrome patients by increased secretion of cytokines.Scand J Immunol. Aug 29. [Epub ahead of print]
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