|Calculated MW||31256 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Mouse CD200-rat CD4 fusion protein.|
|Shelf Life||18 months from date of despatch.|
|Other Names||OX-2 membrane glycoprotein, MRC OX-2 antigen, CD200, Cd200, Mox2|
|Target/Specificity||Rat anti-Mouse CD200 antibody, clone OX-90 recognizes the mouse CD200 cell surface antigen, also known as OX2.CD200 is expressed by splenic B lymphocytes, follicular dendritic cells, splenic endothelium and by neurons.Studies have suggested that the CD200 - CD200 ligand system is of importance in the control of macrophage and granulocyte activation.|
|Preservative & Stabilisers||0.09% Sodium Azide; 1% Bovine Serum Albumin|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CD200 Antibody, clone OX-90 (Biotin) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Hoek, R.M. et al. (2000) Down-regulation of the macrophage lineage through interaction with OX2 (CD200).Science. 290 (5497): 1768-71. 2. Nathan, C. & Muller, W.A. (2001) Putting the brakes on innate immunity: a regulatory role for CD200?Nat Immunol. 2 (1): 17-9. 3. Broderick, C. et al. (2002) Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis.Am J Pathol. 161 (5): 1669-77. 4. Seeds, R.E. et al. (2011) The role of myeloid receptors on murine plasmacytoid dendritic cells in induction of type I interferon.Int Immunopharmacol. 11 (7): 794-801. 5. Burger, P.E. et al. (2009) High aldehyde dehydrogenase activity: a novel functional marker of murine prostate stem/progenitor cells.Stem Cells. 27: 2220-8. 6. Garza, L.A. et al. (2011) Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells.J Clin Invest. 121: 613-22. 7. Ko, Y.C. et al (2009) Endothelial CD200 is heterogeneously distributed, regulated and involved in immune cell-endothelium interactions.J Anat. 214: 183-95. 8. Koning, N. et al. (2009) Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggests neuron-glia and glia-glia interactions.J Neuropathol Exp Neurol. 68: 159-67. 9. Krejsek, J. et al (2010) Expression of CD200/CD200R regulatory molecules on granulocytes and monocytes is modulated by cardiac surgical operation.Perfusion. 25: 389-97. 10. Rijkers, E.S. (2007) Ligation of CD200R by CD200 is not required for normal murine myelopoiesis.Eur J Haematol. 79: 410-6. 11. Rijkers, E.S. et al. (2008) The inhibitory CD200R is differentially expressed on human and mouse T and B lymphocytes.Mol Immunol. 45: 1126-35.
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