|Application ||WB, IHC-F, FC, IP, Func|
|Calculated MW||35534 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Membrane fraction of thioglycollate-elicited rat peripheral cells.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Cell surface glycoprotein CD200 receptor 1, CD200 cell surface glycoprotein receptor, Cell surface glycoprotein OX2 receptor 1, OX102 antigen, Cd200r1, Mox2r, Ox2r|
|Target/Specificity||Mouse anti-Rat CD200 Receptor 1 antibody, clone OX-102 recognizes the rat OX2 (CD200) receptor 1. This antigen is a heavily glycosylated 60-100kDa cell surface molecule expressed by cells of the myeloid lineage but not by T or B lymphocytes.Mouse anti-Rat CD200 Receptor 1 antibody, clone OX-102 has been shown to block the interaction of OX2 receptor 1 with CD200 (Bushellet al.2008).|
|Preservative & Stabilisers||Preservative Free|
|Storage||Store at -20℃ only.|
|Precautions||Anti-Rat CD200 Receptor 1 Antibody, clone OX-102 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Wright, G.J. et al. (2000) Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function.Immunity. 13 (2): 233-42. 2. Nathan, C. & Muller, W.A. (2001) Putting the brakes on innate immunity: a regulatory role for CD200?Nat Immunol. 2 (1): 17-9. 3. Dick, A.D. et al. (2001) Distribution of OX2 antigen and OX2 receptor within retina.Invest Ophthalmol Vis Sci. 42 (1): 170-6. 4. Banerjee, D. & Dick, A.D. (2004) Blocking CD200-CD200 receptor axis augments NOS-2 expression and aggravates experimental autoimmune uveoretinitis in Lewis rats.Ocul Immunol Inflamm. 12 (2): 115-25. 5. Meuth, S.G. et al. (2008) CNS inflammation and neuronal degeneration is aggravated by impaired CD200-CD200R-mediated macrophage silencing.J Neuroimmunol. 194 (1-2): 62-9. 6. Matsumoto, S. et al. (2015) CD200+ and CD200- macrophages accumulated in ischemic lesions of rat brain: the two populations cannot be classified as either M1 or M2 macrophages.J Neuroimmunol. 282: 7-20. 7. Lin Shu S. et al. (2012) Immune Characterization of Wild-Caught Rattus norvegicus Suggests Diversity of Immune Activity in Biome-Normal EnvironmentsJournal of Evolutionary Medicine. 1: 1-16. 8. Nicholls, S.M. et al. (2015) Local targeting of the CD200-CD200R axis does not promote corneal graft survival.Exp Eye Res. 130: 1-8.
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