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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti Human CD91 Antibody, clone A2Mr alpha-2    

Anti-Human CD91 Antibody, clone A2Mr alpha-2 (RPE)

Mouse Anti-Human Monoclonal Antibody

     
  • IF - Anti-Human CD91 Antibody, clone A2Mr alpha-2 (RPE) ABD12358
    Immunofluorescence staining of a human tonsil cryosection with Mouse anti Human CD91 antibody, clone A2Mr alpha-2 , red in A and Mouse anti Human CD21, clone LB21 , green in B. C is the merged image with nuclei counterstained blue using DAPI. High power
  • IF - Anti-Human CD91 Antibody, clone A2Mr alpha-2 (RPE) ABD12358
    Immunofluorescence staining of a human tonsil cryosection with Mouse anti Human CD91 antibody, clone A2Mr alpha-2 , red in A and Mouse anti Human CD21, clone LB21 , green in B. C is the merged image with nuclei counterstained blue using DAPI. Low power
  • IF - Anti-Human CD91 Antibody, clone A2Mr alpha-2 (RPE) ABD12358
    Immunofluorescence staining of a human tonsil cryosection with Mouse anti Human CD91 antibody, clone A2Mr alpha-2 , red in A and Mouse anti Human CD21, clone LB21 , green in B. C is the merged image with nuclei counterstained blue using DAPI. Medium power
  • IHC-P - Anti-Human CD91 Antibody, clone A2Mr alpha-2 (RPE) ABD12358
    Immunoperoxidase staining of a human tonsil cryosection with Mouse anti Human CD91 antibody, clone A2Mr alpha-2 followed by the Histar detection system . Medium power
  • IHC - Anti-Human CD91 Antibody, clone A2Mr alpha-2 (RPE) ABD12358
    Immunoperoxidase staining of a human tonsil cryosection with Mouse anti Human CD91 antibody, clone A2Mr alpha-2 followed by the Histar detection system . Low power
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC
Primary Accession Q07954
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names A2Mr alpha-2
Calculated MW 504606 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen Purified alpha2 macroglobulin receptor
Shelf Life 18 months from date of despatch.
Gene ID 4035
Other Names Prolow-density lipoprotein receptor-related protein 1, LRP-1, Alpha-2-macroglobulin receptor, A2MR, Apolipoprotein E receptor, APOER, CD91, Low-density lipoprotein receptor-related protein 1 85 kDa subunit, LRP-85, Low-density lipoprotein receptor-related protein 1 515 kDa subunit, LRP-515, Low-density lipoprotein receptor-related protein 1 intracellular domain, LRPICD, LRP1, A2MR, APR
Target/Specificity Mouse anti-Human CD91 antibody, clone A2Mr alpha-2 recognizes human CD91, also known as Prolow-density lipoprotein receptor-related protein 1, Alpha-2-macroglobulin receptor or apolipoprotein E receptor. CD91 is a 4525 amino acid protein post translationally cleaved into 3 subunits, a 85kDa type I transmembrane carboxyl chain (LRP85) non-covalently bound to a 515kDa extracellular N-terminal subunit (LRP515)containing multiple EGF-like and LDL-receptor Class AandClass B domains. Additionally, there is an intracellular domain (LRPICD) which can be cleaved from the transmambrane domain by gamma secretase (Mayet al.2004). Clone A2Mr alpha-2 detects an epitope within the LRP515 chain.CD91 is a multifunctional protein involved in processes inluding the phagocytosis and endocytosis of apoptotic cells (Nilssonet al.2012), clearance of activated serum alpha-2-macroglobulin (Kristensenet al.1990), modulation of the inflammatory response (Staudtet al.2013) and acts as a receptor for Pseudomonas aeruginosa exotoxin A (Kounnaset al.1992).Mouse anti-Human CD91, clone A2Mr alpha-2 has been used extensively for the detection of CD91 by flow cytometry and immunohistochemistry on formalin fixed paraffin embedded tissues (Bourazopoulouet al.2009).
Preservative & Stabilisers 0.09% Sodium azide; Stabilising agent
Storage Storage at +4ºC. DO NOT FREEZE.
PrecautionsAnti-Human CD91 Antibody, clone A2Mr alpha-2 (RPE) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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References

1. Moestrup, S.K. et al. (1992) Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues.
Cell Tissue Res. 269 (3): 375-82. 2. Moestrup, S.K. & Hokland, P. (1992) Surface expression of the alpha 2-macroglobulin receptor on human malignant blood cells.
Leuk Res. 16 (3): 227-34. 3. Chen, J.S. et al. (2010) Secreted Heat Shock Protein 90{alpha} Induces Colorectal Cancer Cell Invasion through CD91/LRP-1 and NF-{kappa}B-mediated Integrin {alpha}V Expression.
J Biol Chem. 285: 25458-66. 4. Bourazopoulou, E. et al. (2009) Functional expression of the alpha 2-macroglobulin receptor CD91 in salivary gland epithelial cells.
J Autoimmun. 33: 141-6. 5. Hvidberg, V. et al. (2005) Identification of the receptor scavenging hemopexin-heme complexes.
Blood. 106: 2572-9. 6. Hodge, S. et al. (2006) Azithromycin increases phagocytosis of apoptotic bronchial epithelial cells by alveolar macrophages.
Eur Respir J. 28 (3): 486-95. 7. Hodge, S. et al. (2007) Smoking alters alveolar macrophage recognition and phagocytic ability: implications in chronic obstructive pulmonary disease.
Am J Respir Cell Mol Biol. 37: 748-55. 8. Pawluczyk, I.Z. et al. (2008) Perindoprilat modulates the activity of lipoprotein receptor-related protein in human mesangial cells.
J Biol Chem. 283: 4588-94. 9. Cunnington, A.J. et al. (2012) Prolonged neutrophil dysfunction after Plasmodium falciparum malaria is related to hemolysis and heme oxygenase-1 induction.
J Immunol. 189 (11): 5336-46. 10. Inage, E. et al. (2014) Critical Roles for PU.1, GATA1, and GATA2 in the expression of human FceRI on mast cells: PU.1 and GATA1 transactivate FCER1A, and GATA2 transactivates FCER1A and MS4A2.
J Immunol. 192 (8): 3936-46.

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