|Application ||FC, IP|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Purified H-2Kb and H-2Db MHC-I molecules.|
|Shelf Life||18 months from date of despatch.|
|Target/Specificity||Mouse anti-Mouse MHC Class I antibody, clone 2G5 recognizes a monomorphic epitope present on murine MHC class I molecules, expressed at varying levels on the majority of nucleated cells. The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In mice, this complex is referred to as the histocompatibility 2 (H-2) region.The epitope recognised by clone 2G5 is conformation dependent and is reported to be phylogenetically conserved (Claessonet al.1994). Reactivity has been observed with some canine samples suggesting that this antibody may recognize a polymorphic epitope of canine MHC class I.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse MHC Class I Antibody, clone 2G5 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Claesson, M.H. et al. (1994) Antibodies directed against monomorphic and evolutionary conserved self epitopes may be generated in 'knock-out' mice. Development of monoclonal antibodies directed against monomorphic MHC class I determinants. Scand. J. Immunol. 40: 257-264. 2. Vitadello, M. et al. (2010) Myofiber stress-response in myositis: parallel investigations on patients and experimental animal models of muscle regeneration and systemic inflammation. Arthritis Res Ther.12: R52. 3. Huang, Y.C. et al. (2008) CD5-low expression lymphocytes in canine peripheral blood show characteristics of natural killer cells.J Leukoc Biol. 84 (6): 1501-10. 4. Liu, C.C. et al. (2008) Transient downregulation of monocyte-derived dendritic-cell differentiation, function, and survival during tumoral progression and regression in an in vivo canine model of transmissible venereal tumor.Cancer Immunol Immunother. 57 (4): 479-91. 5. Letellier, M. et al. (2008) Normal adult climbing fiber monoinnervation of cerebellar Purkinje cells in mice lacking MHC class I molecules.Dev Neurobiol. 68 (8): 997-1006. 6. Gupta, A. et al. (2012) Efficacy of Mycobacterium indicus pranii immunotherapy as an adjunct to chemotherapy for tuberculosis and underlying immune responses in the lung.PLoS One. 7 (7): e39215. 7. Giunchetti, R.C. et al. (2007) Immunogenicity of a killed Leishmania vaccine with saponin adjuvant in dogs.Vaccine. 25 (44): 7674-86. 8. Cenci, E. et al. (2006) Modulation of phenotype and function of dendritic cells by a therapeutic synthetic killer peptide.J Leukoc Biol. 79 (1): 40-5. 9. Giunchetti RC et al. (2008) A killed Leishmania vaccine with sand fly saliva extract and saponin adjuvant displays immunogenicity in dogs.Vaccine. 26 (5): 623-38. 10. Patel, G.K. et al. (2012) A humanized stromal bed is required for engraftment of isolated human primary squamous cell carcinoma cells in immunocompromised mice.J Invest Dermatol. 132 (2): 284-90.1. Piriou-Guzylack, L. (2008) Membrane markers of the immune cells in swine: an update.Vet Res. 39: 54.
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