|Application ||WB, IHC-P|
|Calculated MW||54007 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Ovalbumin conjugated synthetic peptide corresponding to a region within the C-terminus of human MMP-1.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Interstitial collagenase, 188.8.131.52, Fibroblast collagenase, Matrix metalloproteinase-1, MMP-1, 22 kDa interstitial collagenase, 27 kDa interstitial collagenase, MMP1, CLG|
|Target/Specificity||Mouse anti Human MMP-1 antibody, clone 3B6 recognizes human matrix metalloproteinase 1 (MMP-1), also known as interstitial or fibroblast collagenase, a 469 amino acid, in the pro-peptide form, zinc-dependent endopeptidase responsible for degrading the extracellular matrix. MMPs are also involved in cell proliferation, migration, differentiation and apoptosis (Chenet al.2013). Most MMP’s are synthesised as inactive zymogens and a propeptide region must be cleaved off before the enzyme becomes active (Nagaseet al.1992). MMP expression is increased dramatically in a variety of cancer types, where it indicates invasive disease and a poor prognosis (Murrayet al.1996).MMP-1 is one of the collagenases, capable of degrading collagens I, II and III, all main components of the interstitial stroma (Robichaudet al.2011). MMP-1 is overexpressed in invasive melanoma, colorectal and esophageal cancers (Langenskiöldet al.2013). MMP-1 has also been implicated in arthritis and may influence atherosclerotic lesion formation (Nikkariet al.1995) . Additionally, MMP-1 has been implicated in the repair processes of the heart after myocardial infarction (Yarbroughet al.2003).Mouse anti Human MMP-1 has been used successfully for the detection of MMP-1 in gastric cancer by both Western blotting and immunohistochemistry (Murrayet al.1998).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human MMP-1 Antibody, clone 3B6 is for research use only and not for use in diagnostic or therapeutic procedures.|
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