|Application ||WB, IF, E, IP|
|Calculated MW||21184 Da|
|Other Species||M,African Green Monkey ,B|
|Purification||Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant|
|Immunogen||A synthetic peptide corresponding to the N-terminal region (aa 3-16) of human Bax having the sequence C-GSGEQPRGGGPTSS.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Apoptosis regulator BAX, Bcl-2-like protein 4, Bcl2-L-4, BAX, BCL2L4|
|Target/Specificity||Mouse anti Human BAX antibody, clone 2D2 recognizes an epitope within the N-terminal (NT) region of human apoptosis regulator BAX, also known as Bcl-2-like protein 4. BAX is a pro-apoptotic member of the Bcl-2 family. BAX accelerates programmed cell death by binding to and antagonizing the apoptosis repressor Bcl-2 or its adenovirus homolog E1B 19k protein. It also induces the release of cytochrome C , activation of caspase-3 and thereby apoptosis. Defects in BAX are found in some cell lines from hematopoietic malignancies as T-cell acute lymphoblastic leukemia, Burkitt lymphoma, and plasmacytoma (Brimmellet al.1998).Mouse anti Human BAX antibody, clone 2D2 has been successfully used for the immunoprecipitation of bovine BAX from thymus (Basañezet al.1999).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human BAX (N-Terminal) Antibody, clone 2D2 is for research use only and not for use in diagnostic or therapeutic procedures.|
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