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Anti Human Caspase-8 Antibody, clone 4-1-20

Mouse Anti-Human Monoclonal Antibody

  • WB - Anti Human Caspase-8 Antibody, clone 4-1-20  ABD12380
    Western blot analysis of C6 rat glioma whole cell lysate probed with Mouse anti Human caspase-8 antibody followed by HRP conjugated Goat anti Mouse IgG, visualized by chemiluminescence
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14790
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 4-1-20
Calculated MW 55391 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Full-length human caspase-8
Shelf Life 18 months from date of despatch.
Gene ID 841
Other Names Caspase-8, CASP-8,, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog, MACH, Caspase-8 subunit p18, Caspase-8 subunit p10, CASP8, MCH5
Target/Specificity Mouse anti Human Caspase 8, clone 4-1-20, specifically recognises human caspase-8, otherwise known as Fas-linked ICE-like protease (FLICE), a cytosolic protein which shares homology with both Fas-associated via death domain (FADD) and the ICE/Ced-3 family of cysteine proteases. Caspase-8 is classified as an initiator caspase and acts as the most upstream trigger of Fas-Receptor (CD95) and tumour necrosis factor receptor 1 (TNFR1) mediated apoptosis. Upon activation, the cell death receptor Fas links with the adaptor molecule FADD via corresponding death domains (DD). FADD in turn then binds via death effector domains (DEDs) to procaspase-8, which then undergoes oligomerization and autocatalytic activation.Active Caspase-8 is capable of cleaving all other known caspases, and also cleaves the Bcl-2 family member BH3-interacting domain death agonist (BID), along with the Bcl-2 associated protein p28Bap31.
Preservative & Stabilisers None present
Storage Store at -20℃ only.
PrecautionsAnti Human Caspase-8 Antibody, clone 4-1-20 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD12380
(40 western blots)
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