|Application ||WB, E|
|Calculated MW||55391 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Full-length human caspase-8|
|Shelf Life||18 months from date of despatch.|
|Other Names||Caspase-8, CASP-8, 188.8.131.52, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog, MACH, Caspase-8 subunit p18, Caspase-8 subunit p10, CASP8, MCH5|
|Target/Specificity||Mouse anti Human Caspase 8, clone 4-1-20, specifically recognises human caspase-8, otherwise known as Fas-linked ICE-like protease (FLICE), a cytosolic protein which shares homology with both Fas-associated via death domain (FADD) and the ICE/Ced-3 family of cysteine proteases. Caspase-8 is classified as an initiator caspase and acts as the most upstream trigger of Fas-Receptor (CD95) and tumour necrosis factor receptor 1 (TNFR1) mediated apoptosis. Upon activation, the cell death receptor Fas links with the adaptor molecule FADD via corresponding death domains (DD). FADD in turn then binds via death effector domains (DEDs) to procaspase-8, which then undergoes oligomerization and autocatalytic activation.Active Caspase-8 is capable of cleaving all other known caspases, and also cleaves the Bcl-2 family member BH3-interacting domain death agonist (BID), along with the Bcl-2 associated protein p28Bap31.|
|Preservative & Stabilisers||None present|
|Storage||Store at -20℃ only.|
|Precautions||Anti Human Caspase-8 Antibody, clone 4-1-20 is for research use only and not for use in diagnostic or therapeutic procedures.|
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