|Application ||FC, E|
|Calculated MW||11749 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Immunogen||Human cytochrome c|
|Shelf Life||18 months from date of despatch.|
|Other Names||Cytochrome c, CYCS, CYC|
|Target/Specificity||ABD12382 recognises cytochrome c, originally termed Apaf-2, an evolutionarily conserved protein which acts as an essential mitochondrial electron carrier between respirable substrates and oxygen, during aerobic energy production. A second major function for cytochrome c is its role as an intermediate in apoptosis, both through its association with inositol-3-phosphate receptor (IP3 receptor) which acts as an ER calcium release channel, and its association with apoptotic protease activating factor 1 (Apaf-1), resulting in the formation of the apoptosome protein complex which then recruits and activates pro-caspase 9 (Apaf-3). Clone 2G8 is reported to block the role of cytochrome c as a co-factor in the activation of caspase 9. Removal of sodium azide is recommended prior to use in functional assays – AbD Serotec recommend the use of EQU003 for this purpose.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Cytochrome C Antibody, clone 2G8 is for research use only and not for use in diagnostic or therapeutic procedures.|
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