|Application ||IHC-F, E, IP|
|Calculated MW||150769 Da|
|Immunogen||Extracellular domain of recombinant human VEGFR-1|
|Shelf Life||18 months from date of despatch.|
|Other Names||Vascular endothelial growth factor receptor 1, VEGFR-1, 22.214.171.124, Fms-like tyrosine kinase 1, FLT-1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, FLT, Vascular permeability factor receptor, FLT1, FLT, FRT, VEGFR1|
|Target/Specificity||ABD12384 specifically recognises an epitope within amino acid residues 1-251 located in the extracellular domain of human VEGF (vascular endothelial growth factor) receptor 1 (VEGFR-1), otherwise known as Flt-1, a tyrosine-kinase receptor expressed by almost all vascular endothelial cells and by some peripheral blood monocytes.VEGFR-1 acts as a receptor for members of the VEGF protein family, playing a key role in vascular development and the regulation of vascular permeability. The signal transduction cascade resulting from VEGFR-1 binding appears to differ from that of VEGFR-2 (KDR), since the proliferation of cells lacking VEGFR-1 can be induced by VEGFR-2 binding, whilst the proliferation of cells lacking VEGFR-2, cannot be induced by VEGFR-1 binding alone.|
|Preservative & Stabilisers||10mM Sodium Azide (NaN3), 10% Foetal Bovine Serum|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human VEGF Receptor 1 Antibody, clone Flt-19 is for research use only and not for use in diagnostic or therapeutic procedures.|
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