|Application ||WB, E|
|Calculated MW||84871 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant|
|Immunogen||Purified human soluble transferrin receptor.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Transferrin receptor protein 1, TR, TfR, TfR1, Trfr, T9, p90, CD71, Transferrin receptor protein 1, serum form, sTfR, TFRC|
|Target/Specificity||Mouse anti Human soluble CD71 antibody, clone 13E4 recognizes the human soluble transferrin receptor (sTfR) also known as CD71 or p90. CD71 is a single pass type II membrane glycoprotein of ~90kDa which forms a homodimeric complex, a truncated form of the membrane bound transferrin receptor lacking the cytoplasmic and transmembrane regions of the molecule (Shihet al.1990). It is responsible for the uptake of iron into the cell, by binding to and internalising iron-bound transferrin (Koganet al.2005). After the iron is released into the cell, the apotransferrin is relocated to the cell surface, cleaved at Arg-100 and released into the circulation. In healthy adults almost all the transferrin receptor exists in the soluble form (Shihet al.1993)The level of soluble CD71 is used to detect erythropoietin misuse by athletes (Borrioneet al.2007). It is also used to diagnose iron deficiency anemia (Kameret al.2012).Mouse anti human soluble CD71, clone 13E4 recognizes human both the soluble transferrin receptor and the complex between soluble transferrin receptor and transferrin.|
|Preservative & Stabilisers||0.09%Sodium Azide|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human CD71 (soluble) Antibody, clone 13E4 is for research use only and not for use in diagnostic or therapeutic procedures.|
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