|Application ||E, Func|
|Clone Names||6B4 IGH 54|
|Calculated MW||24384 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Natural partially purified mouse IL-6.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Interleukin-6, IL-6, B-cell hybridoma growth factor, Interleukin HP-1, Il6, Il-6|
|Target/Specificity||Rat anti Mouse Interleukin-6 antibody, clone 6B4 IGH 54recognizes mouse IL-6 (interleukin-6), a multifunctional pro-inflammatory cytokine secreted by activated T cells, macrophages, endothelial cells, fibroblasts and osteoblasts acts as the primary inducer of the acute phase response in the liver.IL-6 signals through a membrane bound receptor complex consisting of the ligand-binding IL-6Ra chain (CD126) and the signal-transducing component gp130 (CD130). IL-6 can also stimulate cells expressing gp130 through a soluble IL-6R. IL-6 has been shown to stimulate B cell differentiation and subsequent immunoglobulin production, promote hybridoma growth, as well as regulating bone metabolism and stimulating energy mobilisation in muscle and fatty tissue.Rat anti Mouse Interleukin-6 antibody, clone 6B4 IGH 54 can be used to neutralize the activity of 50pg/ml of recombinant mouse IL-6 by >95% in a functional assay.|
|Preservative & Stabilisers||None present|
|Storage||Store at -20℃ only.|
|Precautions||Anti Mouse Interleukin-6 Antibody, clone 6B4 IGH 54 is for research use only and not for use in diagnostic or therapeutic procedures.|
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