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>   home   >   Products   >   Primary Antibodies   >   Anti Human Papillomavirus 18 Oncoprotein E7 Antibody, clone 718-15    

Anti Human Papillomavirus 18 Oncoprotein E7 Antibody, clone 718-15

Mouse Anti-Viral Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P06788
Reactivity Virus
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 718-15
Calculated MW 11995 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Oncoprotein E7 from human papillomavirus 18.
Shelf Life 18 months from date of despatch.
Other Names Protein E7, E7
Target/Specificity Mouse anti Human Papillomavirus 18 Oncoprotein E7 antibody, clone 718-15 recognizes the E7 oncoprotein of human papilloma virus 18. Human papillomavirus (HPV) is a diverse group of DNA-based viruses that infect skin and mucous membranes of humans and animals. Some HPV types are the causative agents of cervical cancer, with types 16 and 18 being particularly high-risk. The viral proteins E6 and E7 disrupts normal cell cycle regulation by interacting with p53 (a tumor-suppressing transcription factor) and Rb (retinoblastoma protein, also a tumor-supressor). E7 particularly binds to Rb and histone deacetylases, resulting in activation of the E2F genes, which code for a family of transcription factors. The viral proteins E6 and E7 might be of particular interest in the development of therapeutic vaccines, since they are expressed early in viral infection. Mouse anti Human Papillomavirus 18 Oncoprotein E7 antibody, clone 718-15 does not cross-react with the E7 protein of HPV-16.
Preservative & Stabilisers 0.09% Sodium azide
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human Papillomavirus 18 Oncoprotein E7 Antibody, clone 718-15 is for research use only and not for use in diagnostic or therapeutic procedures.
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Cat# ABD12438
(40 western blots)
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