Anti Human Papillomavirus 18 Oncoprotein E7 Antibody, clone 718-238
Mouse Anti-Viral Monoclonal Antibody
|Application ||WB, E|
|Calculated MW||11995 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Oncoprotein E7 from human papillomavirus 18.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Protein E7, E7|
|Target/Specificity||Mouse anti Human Papillomavirus 18 Oncoprotein E7 antibody, clone 718-238 recognizes the E7 oncoprotein of human papilloma virus 18. Human papillomavirus (HPV) is a diverse group of DNA-based viruses that infect skin and mucous membranes of humans and animals. Some HPV types are the causative agents of cervical cancer, with types 16 and 18 being particularly high-risk. The viral proteins E6 and E7 disrupts normal cell cycle regulation by interacting with p53 (a tumor-suppressing transcription factor) and Rb (retinoblastoma protein, also a tumor-supressor). E7 particularly binds to Rb and histone deacetylases, resulting in activation of the E2F genes, which code for a family of transcription factors. The viral proteins E6 and E7 might be of particular interest in the development of therapeutic vaccines, since they are expressed early in viral infection. Mouse anti Human Papillomavirus 18 Oncoprotein E7 antibody, clone 718-238 does not cross-react with the E7 protein of HPV-16.|
|Preservative & Stabilisers||0.09% Sodium azide|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Papillomavirus 18 Oncoprotein E7 Antibody, clone 718-238 is for research use only and not for use in diagnostic or therapeutic procedures.|
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