Anti Clostridium tetani Tetanus Toxin Antibody, clone TetH6
Mouse Anti-Bacterial Monoclonal Antibody
|Application ||WB, E, Func|
|Calculated MW||150682 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Supernatant from Clostridium tetani.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Tetanus toxin, 188.8.131.52, Tentoxylysin, Tetanus toxin light chain, Tetanus toxin chain L, Tetanus toxin heavy chain, Tetanus toxin chain H, tetX|
|Target/Specificity||Mouse anti Clostridium tetani Tetanus Toxin antibody, clone TetH6 recognizes the tetanus toxin, a neurotoxin produced by the vegetative spore of Clostridium tetani. The toxin causes tetanus, a disease that is characterised by prolonged contraction of skeletal muscle. World-wide, approximately 1 million cases of tetanus occurs annually, resulting in approximately 300,000 to 500,000 deaths, mostly in developing countries. The tetanus toxin has a molecular weight of approximately 150kDa and consists of a heavy chain (B-chain, 100kDa) and a light chain (A-chain, 50kDa) that are connected by a disulfide bond. The toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits the release of the neurotransmitters GABA and glycine by synaptobrevin-2. This results in overactivity in the muscle. The binding of the toxin to neurons is irreversible.Mouse anti Clostridium tetani Tetanus Toxin antibody, clone TetH6 has toxin neutralising activity.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Clostridium tetani Tetanus Toxin Antibody, clone TetH6 is for research use only and not for use in diagnostic or therapeutic procedures.|
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