|Application ||WB, E|
|Calculated MW||10889 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Protein E7 from human papillomavirus 11.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Protein E7, E7|
|Target/Specificity||Mouse anti Human Papillomavirus 11 Protein E7 antibody, clone 711-66 recognizes the E7 protein of human papilloma virus 11. Human papillomavirus (HPV) is a diverse group of DNA-based viruses that infect skin and mucous membranes of humans and animals. Type 11 HPV is a low risk type that causes anogenital warts and is not linked with cervical cancer. In rare cases HPV-11 may cause respiratory papillomatosis, where warts form on the larynx or other areas of the respiratory tract. The viral protein E7 binds to Rb (retinoblastoma protein) and histone deacetylases, resulting in activation of the E2F genes, which code for a family of transcription factors. This binding is of much lower affinity than the high-risk HPV E7 proteins. The viral proteins E6 and E7 might be of particular interest in the development of therapeutic vaccines, since they are expressed early in viral infection.Mouse anti Human Papillomavirus 11 Protein E7 antibody, clone 711-66 cross-reacts minimally with the E7 protein of HPV-16 and HPV-18.|
|Preservative & Stabilisers||0.09% Sodium azide|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Papillomavirus 11 Protein E7 Antibody, clone 711-66 is for research use only and not for use in diagnostic or therapeutic procedures.|
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