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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti Human C-Peptide Antibody, clone 4H8    

Anti Human C-Peptide Antibody, clone 4H8

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01308
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 4H8
Calculated MW 11981 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Immunogen Recombinant C-peptide.
Shelf Life 18 months from date of despatch.
Gene ID 3630
Other Names Insulin, Insulin B chain, Insulin A chain, INS
Target/Specificity Mouse anti Human C-peptide antibody, clone 4H8 recognizes the human pro-insulin pro-peptide also known as the C-peptide. C-peptide is a 31 amino acid peptide released when proinsulin is cleaved, releasing the α and β insulin chains which form a disulphide linked heterodimer, the active secreted form of insulin within β cells of the islets of Langerhans. When insulin is released from the pancreas into the circulation in response to a rise in serum glucose levels, C-peptide is released in equimolar amounts (Wahrenet al.2000). C-peptide, originally thought to be a biologically inert consequence of insulin processing appears to posess functional qualities, it binds to cell membranes (Rigleret al.1999) leading to increased intracellular Ca2+ concentration and subsequent stimulation of N+, K+-ATPase and endothelial nitric oxide synthase activities (Zhonget al.2004). C-peptide also functions in repair of the muscular layer of arteries (Forst and Hunt 2004) and is a potential agent for the treatment of diabetic vasculopathy (Bhattet al.2014) . Levels of C-peptide can be used to distinguish between type 1 and type 2 diabetes acting as a biomarker for pancreatic β-cell function, consequently reduced in type 1 diabetes (Kimuniet al.2014) and may be elevated in type 2 diabetic patients (Oranet al.2010).Mouse anti Human C-Peptide antibody, clone 4H8 recognizes free C-peptide and proinsulin. It does not cross-react with active human, bovine, porcine, mouse or rat insulin and has been successfully employed for immunoprecipitation of human C-peptide prior to MALDI-TOF mass spectrometric analysis (Oranet al.2010).
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human C-Peptide Antibody, clone 4H8 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD12467
(40 western blots)
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