|Calculated MW||12421 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant|
|Immunogen||Fragments of rat C-peptide conjugated to a carrier protein.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Insulin-1, Insulin-1 B chain, Insulin-1 A chain, Ins1, Ins-1|
|Target/Specificity||Mouse anti Rat C-Peptide antibody, clone CII-11 recognizes rat C-peptide. C-peptide is a 31 amino acid peptide released when proinsulin is split into insulin and C-peptide. In rats, two isoforms of proinsulin exists, the difference is two amino acid residues in the C-peptide, termed C-peptide I and C-peptide II. Proinsulin is split when it is released from the pancreas into the blood in response to a rise in serum glucose levels. C-peptide function is not fully understood, it binds to cell membranes which leads to increased intracellular Ca2+ concentration and subsequent stimulation of N+, K+-ATPase and endothelial nitric oxide synthase activities. C-peptide also functions in repair of the muscular layer of arteries. Mouse anti Rat C-Peptide antibody, clone CII-11 recognizes an epitope in the N-terminal region of rat and mouse C-peptide I and II with almost equal affinity. It reacts very weakly with rat proinsulin.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Rat C-Peptide Antibody, clone CII-11 is for research use only and not for use in diagnostic or therapeutic procedures.|
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