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>   home   >   Products   >   Primary Antibodies   >   Anti Rat CD49d Antibody, clone MRalpha4-1    

Anti Rat CD49d Antibody, clone MRalpha4-1

Mouse Anti-Rat Monoclonal Antibody

     
  • FC - Anti Rat CD49d Antibody, clone MRalpha4-1  ABD12481
    Staining of Rat peripheral blood lymphocytes with Mouse anti Rat CD49d:RPE
  • FC - Anti Rat CD49d Antibody, clone MRalpha4-1  ABD12481
    Staining of Rat peripheral blood lymphocytes with Mouse anti Rat CD49d : Alexa Fluor® 488
  • FC - Anti Rat CD49d Antibody, clone MRalpha4-1  ABD12481
    Staining of Rat peripheral blood lymphocytes with Mouse anti Rat CD49d:FITC
  • FC - Anti Rat CD49d Antibody, clone MRalpha4-1  ABD12481
    Staining of Rat peripheral blood lymphocytes with Mouse anti Rat CD49d:Low Endotoxin
  • FC - Anti Rat CD49d Antibody, clone MRalpha4-1  ABD12481
    Staining of Rat peripheral blood lymphocytes with Mouse anti Rat CD49d : Alexa Fluor® 647
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, IP
Reactivity Rat
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Clone Names MRalpha4-1
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen RBL-2H3 rat basophilic leukaemia cell line.
Shelf Life 18 months from date of despatch.
Target/Specificity Mouse anti Rat CD49d monoclonal antibody, clone MRalpha4-1 recognizes rat CD49d, otherwise known as integrin alpha 4 chain/VLA-4, a ~150 kDa single pass type-1 transmembrane glycoprotein and member of the integrin alpha chain family, which acts as a receptor for fibronectin and CD106 (VCAM-1). CD49d is expressed broadly on T and B lymphocytes, monocytes, thymocytes, mast cells and dendritic cells and is involved in cell-cell interactions, mononuclear cell trafficking to sites of endothelial inflammation, and the adhesion of cells to the extracellular matrix. Clone MRalpha4-1 inhibits the in vitroandin vivo functions of CD49d (Yasudaet al.1995). Studies have shown that in rat Peyer’s patches, clone MRalpha4-1 inhibits the rolling and adherence of lymphocytes to postcapillary venules (PCV), and significantly inhibits the transendothelial migration of T lymphocytes (Tsuzukiet al.1996).
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Rat CD49d Antibody, clone MRalpha4-1 is for research use only and not for use in diagnostic or therapeutic procedures.
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Cat# ABD12481
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