|Application ||WB, IF, E|
|Calculated MW||152464 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Immunogen||Synthetic peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human SOS1.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Son of sevenless homolog 1, SOS-1, SOS1|
|Target/Specificity||Mouse anti Human SOS1 antibody, clone SOS-1 recognizes SOS1 (son of sevenless homolog 1), a ubiquitously expressed 1333 amino acid ~150kDa intracellular protein and bifunctional guanine nucleotide exchange factor (GEF), which plays a role in growth and differentiation signalling pathways and in actin reorganization, by acting as a regulator of Ras and Rac/Rho GTPases.Mutations in the SOS1 gene are responsible for the rare oral overgrowth condition known as gingival fibromatosis 1 (Hartet al.2002), and also the cause of the relatively common autosomal dominant disorder Noonan syndrome type 4 (NS4), characterized by short stature, congenital heart malformation, bleeding diathesis and distinctive facial features (Hannaet al.2009).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti SOS1 Antibody, clone SOS-01 is for research use only and not for use in diagnostic or therapeutic procedures.|
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