|Application ||WB, IF, E|
|Calculated MW||152464 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Immunogen||Synthetic peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human SOS1.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Son of sevenless homolog 1, SOS-1, SOS1|
|Target/Specificity||Mouse anti Human SOS1 antibody, clone SOS-1 recognizes SOS1 (son of sevenless homolog 1), a ubiquitously expressed 1333 amino acid ~150kDa intracellular protein and bifunctional guanine nucleotide exchange factor (GEF), which plays a role in growth and differentiation signalling pathways and in actin reorganization, by acting as a regulator of Ras and Rac/Rho GTPases.Mutations in the SOS1 gene are responsible for the rare oral overgrowth condition known as gingival fibromatosis 1 (Hartet al.2002), and also the cause of the relatively common autosomal dominant disorder Noonan syndrome type 4 (NS4), characterized by short stature, congenital heart malformation, bleeding diathesis and distinctive facial features (Hannaet al.2009).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti SOS1 Antibody, clone SOS-01 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.