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Anti SOS1 Antibody, clone SOS-01

Mouse Anti-Human Monoclonal Antibody

  • WB - Anti SOS1 Antibody, clone SOS-01  ABD12495
    Western blotting analysis of human SOS1 epression on K562 (lane 1) and Raji (lane 2) cell lysates usingMouse anti Human SOS1 antibody , detection is by chemiluminescence
  • IF - Anti SOS1 Antibody, clone SOS-01  ABD12495
    Immunofluorescence analysis of human SOS1 expression on human fibroblasts using Mouse anti Human SOS1 , cells are counterstained for actin and DNA using DAPI
  • IF - Anti SOS1 Antibody, clone SOS-01  ABD12495
    Immunofluorescence analysis of human SOS1 expression on transformed murine fibroblasts using Mouse anti Human SOS1 . Actin is stained green and nuclei blue
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q07889
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names SOS-01
Calculated MW 152464 Da
Additional Information
Other Species M
Purification Purified IgG prepared by affinity chromatography on Protein A
Immunogen Synthetic peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human SOS1.
Shelf Life 18 months from date of despatch.
Gene ID 6654
Other Names Son of sevenless homolog 1, SOS-1, SOS1
Target/Specificity Mouse anti Human SOS1 antibody, clone SOS-1 recognizes SOS1 (son of sevenless homolog 1), a ubiquitously expressed 1333 amino acid ~150kDa intracellular protein and bifunctional guanine nucleotide exchange factor (GEF), which plays a role in growth and differentiation signalling pathways and in actin reorganization, by acting as a regulator of Ras and Rac/Rho GTPases.Mutations in the SOS1 gene are responsible for the rare oral overgrowth condition known as gingival fibromatosis 1 (Hartet al.2002), and also the cause of the relatively common autosomal dominant disorder Noonan syndrome type 4 (NS4), characterized by short stature, congenital heart malformation, bleeding diathesis and distinctive facial features (Hannaet al.2009).
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti SOS1 Antibody, clone SOS-01 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD12495
(40 western blots)
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