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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   Anti Human Prolyl Hydroxylase 1 Antibody, clone PHD112/G7    

Anti Human Prolyl Hydroxylase 1 Antibody, clone PHD112/G7

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96KS0
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names PHD112/G7
Calculated MW 43650 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Full length human PHD1 recombinantly expressed.
Shelf Life 18 months from date of despatch.
Gene ID 112398
Other Names Egl nine homolog 2,, Estrogen-induced tag 6, HPH-3, Hypoxia-inducible factor prolyl hydroxylase 1, HIF-PH1, HIF-prolyl hydroxylase 1, HPH-1, Prolyl hydroxylase domain-containing protein 1, PHD1, EGLN2, EIT6
Target/Specificity Mouse anti Human Prolyl Hydroxylase 1 antibody, clone PHD112/G7 recognizes human prolyl hydroxylase 1 (PHD1), a 44kDa enzyme expressed abundantly in all tissues with the highest expression in testis. Hypoxia inducible factor-1 (HIF-1) is a transcriptional complex, consisting of an alpha and beta subunit, which plays a key role in coordinating the cellular response to hypoxia. During normal oxygen conditions, the alpha subunit of HIF-1 is rapidly degraded, however when hypoxia occurs this degradation is suppressed and HIF-1 activates the transcription of various genes important for survival and adaptation to hypoxia. Prolyl hydroxylase 1 catalyses the hydroxylation of specific prolyl residues within the HIF-1 alpha subunit, thereby targeting this subunit for degradation. Prolyl hydroxylase 1 might also play a role in the regulation of cell growth.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human Prolyl Hydroxylase 1 Antibody, clone PHD112/G7 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD12496
(40 western blots)
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