|Application ||WB, IHC-P|
|Calculated MW||43650 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Full length human PHD1 recombinantly expressed.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Egl nine homolog 2, 18.104.22.168, Estrogen-induced tag 6, HPH-3, Hypoxia-inducible factor prolyl hydroxylase 1, HIF-PH1, HIF-prolyl hydroxylase 1, HPH-1, Prolyl hydroxylase domain-containing protein 1, PHD1, EGLN2, EIT6|
|Target/Specificity||Mouse anti Human Prolyl Hydroxylase 1 antibody, clone PHD112/G7 recognizes human prolyl hydroxylase 1 (PHD1), a 44kDa enzyme expressed abundantly in all tissues with the highest expression in testis. Hypoxia inducible factor-1 (HIF-1) is a transcriptional complex, consisting of an alpha and beta subunit, which plays a key role in coordinating the cellular response to hypoxia. During normal oxygen conditions, the alpha subunit of HIF-1 is rapidly degraded, however when hypoxia occurs this degradation is suppressed and HIF-1 activates the transcription of various genes important for survival and adaptation to hypoxia. Prolyl hydroxylase 1 catalyses the hydroxylation of specific prolyl residues within the HIF-1 alpha subunit, thereby targeting this subunit for degradation. Prolyl hydroxylase 1 might also play a role in the regulation of cell growth.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Prolyl Hydroxylase 1 Antibody, clone PHD112/G7 is for research use only and not for use in diagnostic or therapeutic procedures.|
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