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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   Anti Human Prolyl Hydroxylase 2 Antibody, clone 366G/76/3    

Anti Human Prolyl Hydroxylase 2 Antibody, clone 366G/76/3

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9GZT9
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 366G/76/3
Calculated MW 46021 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen PHD2 amino acids 1-24
Shelf Life 18 months from the date of despatch.
Gene ID 54583
Other Names Egl nine homolog 1,, Hypoxia-inducible factor prolyl hydroxylase 2, HIF-PH2, HIF-prolyl hydroxylase 2, HPH-2, Prolyl hydroxylase domain-containing protein 2, PHD2, SM-20, EGLN1 (HGNC:1232), C1orf12
Target/Specificity Mouse anti Human Prolyl Hydroxylase 2 antibody, clone 366G/76/3 recognizes human prolyl hydroxylase 2 (PHD2), a 46 kDa enzyme expressed abundantly in all tissues with the highest expression in testis. Hypoxia inducible factor-1 (HIF-1) is a transcriptional complex, consisting of an alpha and beta subunit, which plays a key role in coordinating the cellular response to hypoxia. During normal oxygen conditions, the alpha subunit of HIF-1 is rapidly degraded, however when hypoxia occurs this degradation is suppressed and HIF-1 activates the transcription of various genes important for survival and adaptation to hypoxia. Prolyl hydroxylase 2 catalyses the hydroxylation of specific prolyl residues within the HIF-1 alpha subunit, thereby targeting this subunit for degradation.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human Prolyl Hydroxylase 2 Antibody, clone 366G/76/3 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD12497
(40 western blots)
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