|Application ||WB, IHC-P|
|Calculated MW||46021 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||PHD2 amino acids 1-24|
|Shelf Life||18 months from the date of despatch.|
|Other Names||Egl nine homolog 1, 188.8.131.52, Hypoxia-inducible factor prolyl hydroxylase 2, HIF-PH2, HIF-prolyl hydroxylase 2, HPH-2, Prolyl hydroxylase domain-containing protein 2, PHD2, SM-20, EGLN1 (HGNC:1232), C1orf12|
|Target/Specificity||Mouse anti Human Prolyl Hydroxylase 2 antibody, clone 366G/76/3 recognizes human prolyl hydroxylase 2 (PHD2), a 46 kDa enzyme expressed abundantly in all tissues with the highest expression in testis. Hypoxia inducible factor-1 (HIF-1) is a transcriptional complex, consisting of an alpha and beta subunit, which plays a key role in coordinating the cellular response to hypoxia. During normal oxygen conditions, the alpha subunit of HIF-1 is rapidly degraded, however when hypoxia occurs this degradation is suppressed and HIF-1 activates the transcription of various genes important for survival and adaptation to hypoxia. Prolyl hydroxylase 2 catalyses the hydroxylation of specific prolyl residues within the HIF-1 alpha subunit, thereby targeting this subunit for degradation.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Prolyl Hydroxylase 2 Antibody, clone 366G/76/3 is for research use only and not for use in diagnostic or therapeutic procedures.|
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