|Calculated MW||31442 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||B6 mouse FasL/BHK cells|
|Shelf Life||18 months from date of despatch.|
|Other Names||Tumor necrosis factor ligand superfamily member 6, CD95 ligand, CD95-L, Fas antigen ligand, Fas ligand, FasL, CD178, Tumor necrosis factor ligand superfamily member 6, membrane form, Tumor necrosis factor ligand superfamily member 6, soluble form, Receptor-binding FasL ectodomain, Soluble Fas ligand, sFasL, ADAM10-processed FasL form, APL, FasL intracellular domain, FasL ICD, SPPL2A-processed FasL form, SPA, Faslg, Apt1lg1, Cd95l, Fasl, gld, Tnfsf6|
|Target/Specificity||Hamster anti Mouse CD178 antibody, clone MFL4 recognizes both mouse and rat CD178, otherwise known as Fas Ligand/ CD95L, a 40 kDa type II transmembrane glycoprotein and member of the TNF/NGF superfamily, expressed by activated T cells and NK cells, which can be induced on a variety of cells by radiation, heat shock, chemotherapeutic agents and viral infection.CD178 acts as a key effector of cytotoxicity and in the regulation of immune responses. The binding of CD178 to its receptor CD95 (Fas), induces Fas-mediated apoptosis of target cells, and may be involved in the induction of peripheral tolerance and neutrophil chemotaxis. The binding of decoy receptor 3 (DcR3) to CD178 has been shown to inhibit CD178-mediated apoptosis.Hamster anti Mouse CD178 antibody, clone MFL4 is reported to block CD178/CD95 induced apoptosis.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Mouse CD178 Antibody, clone MFL4 is for research use only and not for use in diagnostic or therapeutic procedures.|
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