|Application ||WB, E|
|Calculated MW||63368 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Recombinant human CD73 (amino acids 27-252) purified from E. coli.|
|Shelf Life||18 months from date of despatch.|
|Other Names||5'-nucleotidase, 5'-NT, 188.8.131.52, Ecto-5'-nucleotidase, CD73, NT5E, NT5, NTE|
|Target/Specificity||Mouse anti Human CD73, clone 2B6 recognises human CD73, otherwise known as ecto-5'-nucleotidase, a GPI-anchored enzyme and member of the 5'-nucleotidase family, which catalyzes the dephosphorylation of 5'-mononucleotides into their corresponding nucleosides, and can also mediate co-stimulatory signals in T cell activation (Dianzaniet al.1993).CD73 is expressed by subpopulations of T and B lymphocytes, and increases during lymphocyte development, acting as a lymphocyte maturation marker. A decrease in CD73 activity has been associated with several immunodeficiency disorders including AIDS and Wiskott-Aldrich syndrome, and CD73 is expressed on a variety of lymphomas and leukaemias, including CLL and ALL (Zhaoet al.2011)|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human CD73 Antibody, clone 2B6 is for research use only and not for use in diagnostic or therapeutic procedures.|
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