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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti Human CD279 Antibody, clone 4F12    

Anti Human CD279 Antibody, clone 4F12

Mouse Anti-Human Monoclonal Antibody

  • WB - Anti Human CD279 Antibody, clone 4F12  ABD12548
    Western blot analysis of CD279 expression in cell lysates probed with Mouse anti human CD279, clone 4F12
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15116
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names 4F12
Calculated MW 31647 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Recombinant human CD279 (amino acids 21-167) purified from Escherichia coli.
Shelf Life 18 months from date of despatch.
Gene ID 5133
Other Names Programmed cell death protein 1, Protein PD-1, hPD-1, CD279, PDCD1, PD1
Target/Specificity Mouse anti Human CD279, clone 4F12 recognizes human CD279, otherwise known as PD-1/PDCD1, a type I transmembrane glycoprotein and member of the Ig superfamily, which acts as a co-stimulatory molecule and negative regulator of T-cell activation (Patsoukiset al.2012).CD279 is an immunoinhibitory receptor which interacts with its ligands CD274 (PD-L1) and CD273 (PD-L2) to inhibit the activation and proliferation of T and B cells. CD279 is associated with regulating peripheral tolerance of T cells and preventing autoimmunity and autoimmune diseases, including type I diabetes and rheumatoid arthritis (Okazakiet al.2005).
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human CD279 Antibody, clone 4F12 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD12548
(40 western blots)
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