|Application ||WB, E|
|Calculated MW||31647 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Recombinant human CD279 (amino acids 21-167) purified from Escherichia coli.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Programmed cell death protein 1, Protein PD-1, hPD-1, CD279, PDCD1, PD1|
|Target/Specificity||Mouse anti Human CD279, clone 4F12 recognizes human CD279, otherwise known as PD-1/PDCD1, a type I transmembrane glycoprotein and member of the Ig superfamily, which acts as a co-stimulatory molecule and negative regulator of T-cell activation (Patsoukiset al.2012).CD279 is an immunoinhibitory receptor which interacts with its ligands CD274 (PD-L1) and CD273 (PD-L2) to inhibit the activation and proliferation of T and B cells. CD279 is associated with regulating peripheral tolerance of T cells and preventing autoimmunity and autoimmune diseases, including type I diabetes and rheumatoid arthritis (Okazakiet al.2005).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human CD279 Antibody, clone 4F12 is for research use only and not for use in diagnostic or therapeutic procedures.|
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