|Application ||WB, E|
|Calculated MW||102380 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Recombinant human hexokinase 2 (amino acids 1-917) purified from E. coli.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Hexokinase-2, 188.8.131.52, Hexokinase type II, HK II, Muscle form hexokinase, HK2|
|Target/Specificity||Mouse anti Human Hexokinase 1&2, clone 1A7 recognizes human hexokinase 1 (HK1) and hexokinase 2 (HK2), 102kDa allosteric enzymes of the glycolytic pathway, which catalyse the phosphorylation of glucose to form glucose-6-phosphate (Glc-6-P).Hexokinase 1 is predominantly expressed in the brain while Hexokinase 2 is predominantly expressed in skeletal muscle. Both are members of four distinct mammalian hexokinase isozymes (hexokinase type I to IV), which localize to the outer membrane of mitochondria and is regulated (inhibited) by its product Glc-6-P (Wolfet al.2011)|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Hexokinase 1 & 2 Antibody, clone 1A7 is for research use only and not for use in diagnostic or therapeutic procedures.|
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