|Application ||IHC-F, IF, FC|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Rat CD106-transfected L5178Y cells.|
|Shelf Life||18 months from the date of despatch|
|Other Names||Vascular cell adhesion protein 1, V-CAM 1, VCAM-1, CD106, Vcam1, Vcam-1|
|Target/Specificity||Mouse anti Rat CD106 antibody, clone MR106 specifically recognizes rat CD106, otherwise known as VCAM-1 (vascular adhesion molecule 1), a 110kDa inducible type I transmembrane glycoprotein and member of the immunoglobulin supergene family, which is predominantly expressed on vascular endothelium, and also on bone marrow stromal cells, follicular dendritic cells and some macrophages.CD106 interacts with the lymphocyte homing receptor VLA-4 (alpha4 beta1 integrin) and LPAM-1 (alpha4 beta7 integrin) and mediates leucocyte-endothelial cell adhesion and signal transduction. Expression of CD106 is upregulated following cytokine activation, and endothelial CD106 plays a role in the extravasation of leucocytes from blood vessels during inflammation.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4oC or at -20oC if preferred.|
|Precautions||Anti Rat CD106 Antibody, clone MR106 is for research use only and not for use in diagnostic or therapeutic procedures.|
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