|Calculated MW||22190 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||ACI-S1 rat T-cell lymphoma cell line.|
|Shelf Life||18 months from the date of despatch|
|Other Names||Tumor necrosis factor ligand superfamily member 4, OX40 ligand, OX40L, CD252, Tnfsf4, Ox40l, Txgp1|
|Target/Specificity||Mouse anti Rat CD252 antibody, clone ATM-2 specifically recognizes rat CD252, otherwise known as OX40L or CD134L, a ~22 kDa type II transmembrane glycoprotein and member of the TNF superfamily, expressed by antigen-presenting cells including activated dendritic cells and B cells, and also by vascular endothelium. The interaction of CD252 with its receptor OX40/CD134, acts as a co-stimulator of T cell activation, proliferation and both Th1 and Th2 cytokine production, and is also important in activated B cell proliferation and secretion of immunoglobulins (Igs). CD252/OX40 interaction has been implicated in HTLV-1 associated diseases including myelopathy and adult T cell leukaemia, and also with the autoimmune diseases rheumatoid arthritis and inflammatory bowel disease. Mouse anti Rat CD252 antibody, clone ATM-2 has been shown to block the co-stimulatory activity of CD252 on rat T cell proliferation.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred|
|Precautions||Anti Rat CD252 Antibody, clone ATM-2 is for research use only and not for use in diagnostic or therapeutic procedures.|
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