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Anti Human Factor VIII Antibody, clone RFF-VIIIC/5

Mouse Anti-Human Monoclonal Antibody

  • E - Anti Human Factor VIII Antibody, clone RFF-VIIIC/5  ABD12585
    Recombinant Human Factor VIII detected with Mouse anti Human Factor VIII
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P00451
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names RFF-VIIIC/5
Calculated MW 267009 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Affinity purified human Factor VIII.
Shelf Life 18 months from date of despatch.
Gene ID 2157
Other Names Coagulation factor VIII, Antihemophilic factor, AHF, Procoagulant component, Factor VIIIa heavy chain, 200 kDa isoform, Factor VIIIa heavy chain, 92 kDa isoform, Factor VIII B chain, Factor VIIIa light chain, F8, F8C
Target/Specificity Mouse anti Human Factor VIII antibody, clone RFF-VIIIC/5 recognizes human Factor VIII, an essential blood coagulation factor. Factor VIII is primarily synthesized in the liver and is secreted into the bloodstream where it forms a complex with von Willebrand factor. It is activated through cleavage at various sites, dissociates from the complex and interacts with Factor IXa, in the presence of calcium ions and phospholipids, to convert Factor X to the activated Factor Xa, which in turn activates thrombin. Thrombin cleaves fibrinogen into fibrin, which polymerises and cross-links to form a blood clot. The activated Factor VIII is proteolytically inactivated and cleared from the bloodstream. Defects in Factor VIII cause haemophilia A, a disorder characterised by the body’s inability to control blood clotting. This could result in severe blood loss, even with minor injuries. Mouse anti Human Factor VIII antibody, clone RFF-VIIIC/5 recognizes an epitope towards the C-terminus of full-length Factor VIII. It also recognizes the 80 kDa and 70 kDa cleavage products.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human Factor VIII Antibody, clone RFF-VIIIC/5 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD12585
(40 western blots)
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