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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   Anti Human Cytochrome B245 Light Chain Antibody, clone CS9    

Anti Human Cytochrome B245 Light Chain Antibody, clone CS9

Mouse Anti-Human Monoclonal Antibody

     
  • FC - Anti Human Cytochrome B245 Light Chain Antibody, clone CS9  ABD12594
    Staining of human peripheral blood granulocytes with Mouse anti Human Cytochrome b-245 Light Chain:FITC . Permeabilised with Leucoperm
  • FC - Anti Human Cytochrome B245 Light Chain Antibody, clone CS9  ABD12594
    Staining of human peripheral blood granulocytes with Mouse anti Human Cytochrome b-245 Light Chain . Permeabilised with Leucoperm
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-F, FC, E, IP
Primary Accession P13498
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names CS9
Calculated MW 21013 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Cytochrome B245 solubilised in octyl-beta-gluycopyranoside.
Shelf Life 18 months from date of despatch.
Gene ID 1535
Other Names Cytochrome b-245 light chain, Cytochrome b(558) alpha chain, Cytochrome b558 subunit alpha, Neutrophil cytochrome b 22 kDa polypeptide, Superoxide-generating NADPH oxidase light chain subunit, p22 phagocyte B-cytochrome, p22-phox, p22phox, CYBA
Target/Specificity Mouse anti Human Cytochrome B245 Light Chain antibody, clone CS9 recognizes the light chain of cytochrome B245, also known as p22phox, a subunit of the nicotinamide adenine dinucleotide phosphate-oxidase (NADPH oxidase). NADPH oxidase is a membrane-bound enzyme complex in neutrophils that produces the superoxide anion (O2-) by transferring single electrons from NADPH inside the cell across the membrane and coupling them to molecular oxygen. Superoxide is used for the destruction of pathogens. Individuals with defects in NADPH oxidase suffer from chronic granulomatous disease, characterised by severe recurrent infections. The light chain (p22phox), along with the heavy chain (gp91phox) form cytochrome B245 (also known as flavocytochome b, or Cyt b), which is always membrane-resident. Upon the appropriate stimulus, other components of NADPH oxidase (p47phox, p40phox, p67phox and Rac2) rapidly translocate from the cytosol to the cell membrane to form the complete enzyme complex. Cytochrome B245 appears to serve as a scaffold for the assembly of the other cytosolic units of the oxidase and to provide a transmembrane pathway for electrons. The core region of the CS9 epitope is amino acids 165 - 169 (KKPSE), a cytosolic epitope on p22phox not accessible on intact neutrophils. Mouse anti Human Cytochrome B245 Light Chain antibody, clone CS9 also has an inhibitory effect on NADPH oxidase activation.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human Cytochrome B245 Light Chain Antibody, clone CS9 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD12594
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