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Anti Human CD41 Antibody, clone MM2/356

Mouse Anti-Human Monoclonal Antibody

  • FC - Anti Human CD41 Antibody, clone MM2/356  ABD12596
    Staining of human peripheral blood platelets with Mouse anti Human CD41
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08514
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names MM2/356
Calculated MW 113377 Da
Additional Information
Other Species Pig,Mink,Mustelid
Purification Tissue Culture Supernatant containing 0.2M Tris/HCl pH7.4 and 5-10% foetal calf serum
Immunogen Human platelet membranes.
Shelf Life 18 months from date of despatch.
Gene ID 3674
Other Names Integrin alpha-IIb, GPalpha IIb, GPIIb, Platelet membrane glycoprotein IIb, CD41, Integrin alpha-IIb heavy chain, Integrin alpha-IIb light chain, form 1, Integrin alpha-IIb light chain, form 2, ITGA2B, GP2B, ITGAB
Target/Specificity Mouse anti Human CD41 antibody, clone MM2/356 recognises human Integrin alpha-IIb, also known as CD41 or Platelet membrane glycoprotein IIb. CD41 is a 1039 amino acid, including a 31 amino acid signal peptide ~115 kDa single pass type 1 transmembrane glycoprotein expressed by platelets and megakaryocytes. CD41 is involved in the rapid repair of endothelial integrity following injury, causing platelet aggregation through soluble fibrinogen binding and physically plugging the injured endothelial surface (Simon et al.2011).Mutations in the ITGA2B gene can lead to the development of coagulation disorders including Glanzmann thrombasthenia (GT), an inherited disease of platelet aggregation characterized by mucocutaneous bleeding (Wilcoxet al.1995) and Bleeding disorder, platelet-type 16 (BDPLT16), a congenital macrothrombocytopenia associated with platelet anisocytosis (Kunishimaet al.2011).
Preservative & Stabilisers 0.09%Sodium Azide
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human CD41 Antibody, clone MM2/356 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD12596
(40 western blots)
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