|Application ||FC, IP|
|Calculated MW||113377 Da|
|Purification||Tissue Culture Supernatant containing 0.2M Tris/HCl pH7.4 and 5-10% foetal calf serum|
|Immunogen||Human platelet membranes.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Integrin alpha-IIb, GPalpha IIb, GPIIb, Platelet membrane glycoprotein IIb, CD41, Integrin alpha-IIb heavy chain, Integrin alpha-IIb light chain, form 1, Integrin alpha-IIb light chain, form 2, ITGA2B, GP2B, ITGAB|
|Target/Specificity||Mouse anti Human CD41 antibody, clone MM2/356 recognises human Integrin alpha-IIb, also known as CD41 or Platelet membrane glycoprotein IIb. CD41 is a 1039 amino acid, including a 31 amino acid signal peptide ~115 kDa single pass type 1 transmembrane glycoprotein expressed by platelets and megakaryocytes. CD41 is involved in the rapid repair of endothelial integrity following injury, causing platelet aggregation through soluble fibrinogen binding and physically plugging the injured endothelial surface (Simon et al.2011).Mutations in the ITGA2B gene can lead to the development of coagulation disorders including Glanzmann thrombasthenia (GT), an inherited disease of platelet aggregation characterized by mucocutaneous bleeding (Wilcoxet al.1995) and Bleeding disorder, platelet-type 16 (BDPLT16), a congenital macrothrombocytopenia associated with platelet anisocytosis (Kunishimaet al.2011).|
|Preservative & Stabilisers||0.09%Sodium Azide|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human CD41 Antibody, clone MM2/356 is for research use only and not for use in diagnostic or therapeutic procedures.|
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