|Calculated MW||105975 Da|
|Purification||Purified IgG prepared by affinity chromatography|
|Shelf Life||18 months from date of despatch.|
|Other Names||Probable ATP-dependent RNA helicase DDX58, 220.127.116.11, DEAD box protein 58, RIG-I-like receptor 1, RLR-1, Retinoic acid-inducible gene 1 protein, RIG-1, Retinoic acid-inducible gene I protein, RIG-I, Ddx58|
|Target/Specificity||Rat anti Mouse RIG-I antibody, clone SS1A recognises mouse Probable ATP-dependent RNA helicase DDX58, also known as RIG-1, Retinoic acid-inducible gene 1 protein, DEAD-box protein 58 or RIG-I-like receptor 1. RIG-I is a 926 amino acid ~105 kDa innate immune receptor found in the cytoplasm that recognises viral RNA from replicating viruses in infected cells. Upon activation with intracellular RNA, a cascade is triggered resulting in the activation of NF-kappa-B, and the eventual induction of antiviral cytokines such as IFN-beta and RANTES. RIG-I is essential for the production of interferons in response to RNA viruses and as such play a key role in innate immunity (Katoet al.2005).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Mouse RIG-I Antibody, clone SS1A is for research use only and not for use in diagnostic or therapeutic procedures.|
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