|Application ||WB, IHC-F, FC|
|Calculated MW||13911 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Human CD266 transfected P815 cells.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Tumor necrosis factor receptor superfamily member 12A, Fibroblast growth factor-inducible immediate-early response protein 14, FGF-inducible 14, Tweak-receptor, TweakR, CD266, TNFRSF12A, FN14|
|Target/Specificity||Mouse anti Human CD266 antibody, clone ITEM-4 recognizes human Tumor necrosis factor receptor superfamily member 12A, also known as CD266, Fibroblast growth factor-inducible immediate-early response protein 14 or Tweak-receptor. CD266 is a 102 amino acid ~14 kDa type I transmembrane glycoprotein and member of the tumour necrosis factor receptor superfamily (TNFRSF12A) expressed by a variety of tissues, including the heart, lung and kidney, and at elevated levels by human brain and liver tumours.The interaction between CD266 and its ligand CD255 (TWEAK), induces the proliferation and migration of endothelial cells and also angiogenesis, and studies have shown that CD255-induced apoptosis of some tumour cell lines is mediated by CD266 (Nakayamaet al.2003).Mouse anti Human CD266 antibody, clone ITEM-4 is cross-reactive with mouse CD266, and also with Rat-1 fibroblastoid cells in flow cytometry.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human CD266 Antibody, clone ITEM-4 is for research use only and not for use in diagnostic or therapeutic procedures.|
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