|Application ||WB, IHC-P, IHC-F, FC, IP|
|Calculated MW||70021 Da|
|Purification||Purified IgG prepared by affinity chromatography|
|Immunogen||Inflamed mouse skin.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Endoglin, Cell surface MJ7/18 antigen, CD105, Eng, Edg|
|Target/Specificity||Rat anti Mouse CD105 antibody, clone MJ7/18 recognizes mouse CD105, also known as Endoglin, a cell surface glycoprotein member of the TGF beta receptor complex. CD105 is a homodimer that forms a heteromeric complex with TGF beta receptors I and/or II. The complex binds TGF beta 1 and 3 efficiently, and TGF beta 2 less efficiently. It may also play a role in the binding of endothelial cells to integrins and cytoskeletal organisation. It is involved in cardiovascular development. CD105 is expressed on endothelial cells in all tissues except bone marrow and in also found in stromal cells within the connective tissue of the intestine, stomach and heart. It may be a useful marker for proliferating endothelium in tumours.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Mouse CD105 Antibody, clone MJ7/18 is for research use only and not for use in diagnostic or therapeutic procedures.|
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