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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   Anti Mouse P2X7 Antibody, clone Hano43    

Anti Mouse P2X7 Antibody, clone Hano43

Rat Anti-Mouse Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Z1M0
Reactivity Mouse
Host Rat
Clonality Monoclonal
Isotype IgG2b
Clone Names Hano43
Calculated MW 68388 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen A P2X7-expression construct and a final boost with P2X7-transfected HEK cells.
Shelf Life 18 months from date of despatch.
Gene ID 18439
Other Names P2X purinoceptor 7, P2X7, ATP receptor, P2Z receptor, Purinergic receptor, P2rx7, P2x7
Target/Specificity Rat anti Mouse P2X7 antibody, clone Hano43 recognizes the P2X purinoceptor 7, also known as P2X7. The P2X7 ATP receptor has a distinctive long C-terminal tail with multiple potential protein and lipid interaction motifs and is highly polymorphic. It is a cation selective ion channel that opens up on binding of extracellular ATP. Sustained activation by extracellular ATP results in the formation of a reversible pore in the plasma membrane that is permeable to hydrophilic solutes of up to 900 Da. Once a pore is opened massive upset of cytoplasmic ion homeostasis occurs and the pore stays open as long as it is bound by ATP. Should ATP stimulation continue the cell will become irreversibly damaged and die. P2X7 plays a key role in the maturation and release of IL-1 and other IL-1 family members during inflammation. As such, P2X7 blockers might be useful as anti-inflammatory agents.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Mouse P2X7 Antibody, clone Hano43 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD12617
(40 western blots)
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