|Application ||IHC-F, FC, IP|
|Other Accession||Q9WVS0, Q9Y6W8|
|Calculated MW||22529 Da|
|Purification||Purified IgG prepared by affinity chromatography|
|Immunogen||Mouse T cell clone D10.G4.1.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, CD278, Icos, Ailim|
|Target/Specificity||Hamster anti Mouse CD278 antibody, clone C398.4A recognizes CD278, also known as Inducible T cell costimulator or ICOS, a CD28-superfamily costimulatory molecule. It is expressed on activated T cells and resting memory T cells. It enhances all the basic T cell responses to a foreign antigen, namely proliferation, secretion of lymphokines and up-regulation of molecules that mediate cell-cell interaction. It is essential for the efficient interaction between B and T cells and is involved in antibody responses to T cell dependent antigens. It up-regulates the synthesis of interleukin-10, but not interleukin-2 and prevents the apoptosis of pre-activated T cells. Hamster anti Mouse CD278 antibody, clone C398.4A has been reported to costimulate T cell activation and proliferation in vitro.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Mouse CD278 Antibody, clone C398.4A is for research use only and not for use in diagnostic or therapeutic procedures.|
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