|Application ||WB, IHC-P, E|
|Calculated MW||38007 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Synthetic peptide C-D-E-D-Q-D-Y-S-F-P-I-S-S-I-L-E-W corresponding to the C-terminal region of human FS315.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Follistatin, FS, Activin-binding protein, FST|
|Target/Specificity||ABD12628 specifically recognises an epitope within the C-terminal (CT) region of human follistatin 315 (FS315). Follistatin (FST) is a single-chain glycosylated protein of gonadal origin, originally identified as an antagonist of activin and suppressor of follicle stimulating hormone (FSH) synthesis/secretion. Alternative splicing of FST mRNA generates the two isoforms FS315 and FS288, the latter of which is the main cell-surface form and binds with high affinity to surface heparan sulphate proteoglycans, whilst FS315 binds with only low-affinity, and is considered to be the main circulating form of follistatin. As well as activin, FST interacts with other growth factors such as bone morphogenetic proteins (BMPs) -2, -4 and -7, myostatin, and growth differentiation factor 9 (GDF-9), playing a key role in cellular differentiation/proliferation, embryonic development and tissue repair. Studies have shown that clone H10 does not cross-react with FS288, see McPherson, S.J. et al. for details.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Follistatin 315 (C-Terminal) Antibody, clone H10 is for research use only and not for use in diagnostic or therapeutic procedures.|
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