|Application ||WB, IHC-F, IF, E, IP|
|Other Accession||P00355, P16858, P04406, P04797|
|Calculated MW||35780 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant|
|Immunogen||Human cardiac muscle GADPH.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, 188.8.131.52, Peptidyl-cysteine S-nitrosylase GAPDH, 2.6.99.-, GAPDH, GAPD|
|Target/Specificity||Mouse anti Human GAPDH antibody, clone 4G5 recognizes glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a 36 kDa protein whose main function is to catalyse the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate, in conjunction with inorganic phosphate and nicotinamide adenine dinucleotide (NAD). This reaction is an important energy yielding step in carbohydrate metabolism. GAPDH has also been shown to translocate to the nucleus under a variety of stressors, most of which are associated with oxidative stress, whereby it mediates cell death (Chuang & Ishitani 1996). GAPDH binds to several proteins responsible for neurodegenerative diseases, such as amyloid precursor protein and Huntingtin (Burkeet al.1996).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human GAPDH Antibody, clone 4G5 is for research use only and not for use in diagnostic or therapeutic procedures.|
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