|Application ||WB, IHC-P, IP|
|Calculated MW||39008 Da|
|Other Species||Mammalian species,Amphibia|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Shelf Life||18 months from date of despatch.|
|Other Names||Rhodopsin, RHO|
|Target/Specificity||Mouse anti Rhodopsin antibody, clone 1D4 recognises the sequence TETSQVAPA corresponding to aa 340 to 348 of bovine rhodopsin, a pigment of the retina responsible for the formation of photoreceptor cells and the first events in the perception of light. Rhodopsin consists of the protein opsin and a reversibly bound cofactor, retinal, a photoreactive chromophore. Upon light absorption the 11-cis-retinal is isomerised to all-trans retinal, leading to a change in the shape of rhodopsin. The change activates the associated G protein and triggers a second messenger cascade, eventually resulting in the transmission of a nerve impulse to the brain. The trans-retinal is released and converted back into 11-cis-retinal for re-entry into the cycle.Defects in the gene cause various retinopathies such as retinitis pigmentosa and X-linked congenital stationary night blindness.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Rhodopsin Antibody, clone 1D4 is for research use only and not for use in diagnostic or therapeutic procedures.|
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