|Application ||WB, IHC-P, FC, E|
|Calculated MW||23954 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Synthetic peptide corresponding to amino acids 185-198 of human AID.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Single-stranded DNA cytosine deaminase, 188.8.131.52, Activation-induced cytidine deaminase, Cytidine aminohydrolase, AICDA, AID|
|Target/Specificity||Rat anti Human AID antibody, clone EK2-5G9 recognizes human Single-stranded DNA cytosine deaminase, also known as Activation-induced cytidine deaminase or Cytidine aminohydrolase. AID is a 198 amino acid ~24 kDa RNA-editing enzyme essential for the initiation of immunoglobulin class switch recombination, somatic hypermutation and gene conversion.AID is selectively expressed by germinal centre B cells and B cell-derived lymphomas (Bassoet al.2012). Mutation in the AICDA gene is responsible for the autosomal recessive condition Immunodeficiency with hyper-IgM 2 (HIGM2) A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE resulting in extreme susceptibility to bacterial infection.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human AID Antibody, clone EK2-5G9 is for research use only and not for use in diagnostic or therapeutic procedures.|
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