|Calculated MW||24527 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Mouse TREM-2 Fc fusion protein.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Triggering receptor expressed on myeloid cells 2, TREM-2, Triggering receptor expressed on monocytes 2, Trem2, Trem2a, Trem2b, Trem2c|
|Target/Specificity||Rat anti Mouse Trem-2 antibody, clone 78.18 recognizes Triggering receptor expressed on myeloid cells 2 (TREM-2), an activating receptor of the Ig superfamily. TREM-2 forms a receptor signalling complex with DAP12 to trigger the activation of the immune response in macrophages and dendritic cells. It may be involved in chronic inflammation and may promote the production of constitutive rather than inflammatory chemokines and cytokines. TREM-2 may also have a functional role in osteoclast formation. Stimulation of TREM-2 with Rat anti Mouse Trem-2 antibody, clone 78.18 enhances multinucleated osteoclast formation in vitro. Clone 78.18 may also be used to block TREM-2 on pre-osteoclasts to inhibit the formation of multinuclear osteoclasts and to inhibit bone resorption by mature osteoclasts.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Mouse Trem-2 Antibody, clone 78.18 is for research use only and not for use in diagnostic or therapeutic procedures.|
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