|Application ||IHC-P, IHC-F, FC|
|Calculated MW||40322 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Shelf Life||18 months from the date of despatch|
|Other Names||Leukosialin, Galactoglycoprotein, GALGP, Leukocyte sialoglycoprotein, Sialophorin, CD43, SPN, CD43|
|Target/Specificity||Mouse anti Human CD43 antibody, clone DFT-1 recognizes human CD43 also known as leukosialin or sialophorin. CD43 is a 381 amino acid single pass type I transmembrane glycoprotein present on the cell surface of multiple cell types including thymocytes, T-lymphocytes, neutrophils, plasma cells and platelets. It is lacking on the surface of most B-lymphocytes. CD34 is a major membrane sialoglycoprotein expressed on T lymphocytes as two predominant glycoforms, a 115kDa form present on all T-cells and a 130kDa form indicitive of T-cell activation (Barrenet al.1997) and acts as a T-cell counter-receptor for CD169/Siglec-1(van den Berg et al.2001). Clone DFT-1 binds to both glycoforms of human CD43 (Kyoizumiet al.2004)CD34 expression is deficient and/or defective in patients suffering from the X-linked chromocomal immunodeficiency condition Wiskott-Aldrich syndrome and acts as a ligand for CD54(Rosensteinet al.1991). Mouse anti human CD43, clone DFT-1 has been used successfully for the evaluation of CD43 expression in patients with Myelodysplastic syndromes (Kyriakouet al.2006)|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human CD43 Antibody, clone DFT-1 is for research use only and not for use in diagnostic or therapeutic procedures.|
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