|Application ||WB, IHC-P, IHC-F, Func|
|Other Accession||O60383, O77681|
|Calculated MW||49649 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Tuberculin coupled synthetic peptide VPAKYSPLSVLTIEPDGSIAYKEYEDMIATKC from near the C-terminal region of mature human GDF9.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Growth/differentiation factor 9, GDF-9, Gdf9, Gdf-9|
|Target/Specificity||Mouse anti Human GDF9 antibody, clone mAb-GDF9-53 recognizes an epitope within the highly conserved EPDG sequence of GDF9 (growth differentiation factor 9), a 454 amino acid ~51 kDa pro-protein which is cleaved to form a ~17.5 kDa GDF9 monomer which self associates to form an active homodimeric growth factor, a member of the TGF-beta superfamily, closely related to bone morphogenetic proteins (BMPs).GDF9 is expressed by oocytes, playing a vital role in ovarian folliculogenesis, normal follicle development, and fertility. GDF9 signals through binding to bone morphogenetic protein type II receptor (BMPRII), and apparent subsequent activation of TGF-beta type I receptor, otherwise known as activin receptor-like kinase-5 (ALK-5).Mouse anti Human GDF9 antibody, clone mAb-GDF9-53 recognises GDF9 with high immuno-affinity, and has been shown to neutralize GDF9 biological activity (Gilchristet al.2004,Dragovic et al. 2005).Removal of sodium azide is recommended prior to use in functional assays – AbD Serotec recommend the use of EQU003 for this purpose.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human GDF9 Antibody, clone mAb-GDF9-53 is for research use only and not for use in diagnostic or therapeutic procedures.|
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