|Calculated MW||92670 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Recombinant human HIF1 alpha|
|Shelf Life||18 months from the date of despatch.|
|Other Names||Hypoxia-inducible factor 1-alpha, HIF-1-alpha, HIF1-alpha, ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, Class E basic helix-loop-helix protein 78, bHLHe78, Member of PAS protein 1, PAS domain-containing protein 8, HIF1A, BHLHE78, MOP1, PASD8|
|Target/Specificity||Mouse anti Human HIF1 alpha antibody, clone Halpha111a recognizes human Hypoxia-inducible factor 1-alpha otherwise known as HIF1 alpha (HIF1A) or ARNT interacting protein, a widely expressed bHLH-PAS transcription factor, which acts as a critical regulatory protein in the host response to hypoxia (Kubiset al.2005).HIF1A and HIF1B form the highly-conserved heterodimeric HIF-1 transcriptional complex (Carmelietet al.1998). During hypoxic conditions, HIF1A accumulates in the nucleus and activates the transcription of many genes encoding proteins involved in the production of oxygen delivery and metabolic adaptation, such as vascular endothelial growth factorandglucose transporters. Under normal oxygen conditions, HIF1A is targeted by HIF prolyl-hydroxylases, followed by rapid protease degradation, which is inhibited during hypoxia (Hirsiläet al.2003). Overexpression of HIF1A occurs in many common human cancers, including pancreatic, bladder and renal carcinomas (Shibajiet al.2003).Mouse anti Human HIF1α, clone Halpha111a has been successfully used for the identifcation of HIF1α in human samples by both immunohistochemistry and Western blotting.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human HIF1 Alpha Antibody, clone Halpha111a is for research use only and not for use in diagnostic or therapeutic procedures.|
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