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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   Anti Human Glutamate Decarboxylase 2 (N-Terminal) Antibody, clone N-GAD65    

Anti Human Glutamate Decarboxylase 2 (N-Terminal) Antibody, clone N-GAD65

Mouse Anti-Human Monoclonal Antibody

     
  • IHC - Anti Human Glutamate Decarboxylase 2 (N-Terminal) Antibody, clone N-GAD65  ABD12698
    Immunoperoxidase staining of human pancreas cryosection with Mouse anti Human glutamate decarboxylase 2 antibody, clone N-GAD65 followed by Histar detection system . High power
  • IHC - Anti Human Glutamate Decarboxylase 2 (N-Terminal) Antibody, clone N-GAD65  ABD12698
    Human brain lysate probed with Mouse anti Human Glutamine Decarboxylase 2 followed by Goat anti Mouse IgG H+L:DyLight®800
  • IHC - Anti Human Glutamate Decarboxylase 2 (N-Terminal) Antibody, clone N-GAD65  ABD12698
    Immunoperoxidase staining of human pancreas cryosection with Mouse anti Human glutamate decarboxylase 2 antibody, clone N-GAD65 followed by Histar detection system . Low power
  • IHC - Anti Human Glutamate Decarboxylase 2 (N-Terminal) Antibody, clone N-GAD65  ABD12698
    Immunoperoxidase staining of human pancreas cryosection with Mouse anti Human glutamate decarboxylase 2 antibody, clone N-GAD65 followed by Histar detection system . Medium power
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IP
Primary Accession Q05329
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names N-GAD65
Calculated MW 65411 Da
Additional Information
Other Species RatPr
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Keyhole Limpet Haemocyanin (KLH) conjugated synthetic peptide sequence PGSGFWSFGSEDGSGDSEN corresponding to amino acids 4-22 within the N-terminal region of human GAD65.
Shelf Life 18 months from date of despatch.
Gene ID 2572
Other Names Glutamate decarboxylase 2, 4.1.1.15, 65 kDa glutamic acid decarboxylase, GAD-65, Glutamate decarboxylase 65 kDa isoform, GAD2, GAD65
Target/Specificity Mouse anti Human Glutamate Decarboxylase 2 (N-Terminal) antibody, clone N-GAD65 recognizes human glutamate decarboxylase 2, also known as 65 kDa glutamic acid decarboxylase, Glutamate decarboxylase 65 kDa isoform or GAD-65. Glutamate decarboxylase 2 is a 585 amino acid ~65 kDa lipid anchored membrane associated protein responsible for catalysis of γ-aminobutyric acid (GABA) production, the major inhibitory neurotransmitter in the central nervous system (Fenaltiet al.2007) and is expressed in the brain and pancreatic beta cells. Glutamate decarboxylase 2 is the 65 kDa isoform of glutamate decarboxylase, encoded by the GAD2 gene and predominantly expressed by nerve termini, as opposed to the 67 kDa isoform (GAD67), predominantly found in the cell body, and encoded by the GAD1 gene. Autoantibodies to Glutamate decarboxylase 2 are detected in autoimmune diseases, including Graves disease (Kallmannet al.1997), Stiff Man Syndrome (Rajuet al.2005) and are most prevalent in patients with Type I diabetes mellitus or those at high risk of developing Type I diabetes (Petersenet al.1994). The N-Terminal region of GAD65 is essential for targeting the enzyme to GABA-containing secretory vesicles (Shiet al.1994).Mouse anti Human Glutamate Decarboxylase 2 (N-Terminal) antibody, clone N-GAD65 recognizes GAD65 but does not recognize GAD67 (Hampe et al.2001).
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human Glutamate Decarboxylase 2 (N-Terminal) Antibody, clone N-GAD65 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD12698
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