|Application ||WB, E, IP|
|Calculated MW||24008 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant|
|Immunogen||Free human cardiac Troponin I.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Troponin I, cardiac muscle, Cardiac troponin I, TNNI3, TNNC1|
|Target/Specificity||Mouse anti Human Troponin I (Cardiac) antibody, clone 441 recognizes human cardiac Troponin I (cTnI). Troponin I is a 24kDa subunit of Troponin, a protein found on muscle tissue responsible for muscle contraction. When calcium binds to Troponin C, a conformational change moves Troponin I and tropomyosin out of the way of the myosin binding sites on the actin filaments in muscles. This allows cross-bridging to occur and the muscle to contract. Levels of cTnI in serum are commonly used as a marker for cardiac cell damage and death. Mouse anti Human Troponin I (Cardiac) antibody, clone 441 recognizes an epitope between amino acid residues 148 - 158 and does not cross react with skeletal TnI.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Troponin I (Cardiac) Antibody, clone 441 is for research use only and not for use in diagnostic or therapeutic procedures.|
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