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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti Human Sulfatase 2 (C-Terminal) Antibody, clone 2B4    

Anti Human Sulfatase 2 (C-Terminal) Antibody, clone 2B4

Mouse Anti-Human Monoclonal Antibody

  • IHC-P - Anti Human Sulfatase 2 (C-Terminal) Antibody, clone 2B4  ABD12714
    Paraffin embedded HEK293 cells transfected with SULF2 stained with Mouse anti Human Sulfatase 2 C-terminal
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8CFG0
Other Accession Q8IWU5
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 2B4
Calculated MW 100497 Da
Additional Information
Other Species M
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Recombinant human Sulf-2
Shelf Life 18 months from date of despatch.
Gene ID 72043
Other Names Extracellular sulfatase Sulf-2, mSulf-2, 3.1.6.-, Sulf2
Target/Specificity Mouse anti Human Sulfatase 2 (C-Terminal) antibody, clone 2B4 recognizes an epitope within the C-terminal (CT) subunit of Sulfatase 2 (Sulf-2). Sulf-2 is a novel extracellular heparan sulfate 6-O-endosulfatase, which selectively removes the critical sulfate group from the polysaccharide side chain of heparan sulfate proteoglycans, major components of the extracellular matrix, involved in cell differentiation, proliferation and migration. Sulf-2 acts as a modulator of several signalling proteins including Wnt proteins, bone morphogenetic proteins (BMPs) and fibroblast growth factors (FGFs), and is a direct transcriptional target of p53. Studies have linked Sulf-2 with several cancers, including breast, hepatocellular, and pancreatic cancer, and recently with non-small-cell lung carcinomas (Lemjabbar-Alaouiet al.2010).Mature human Sulf-2 is a heterodimer consisting of a 50kDa C-terminal subunit, essential for both glucosamine 6-O-sulfate-endosulfatase and arylsulfatase activity, and a 75kDa N-terminal subunit which contains the catalytic centre. Mouse anti Human Sulfatase 2 (C-Terminal) antibody, clone 2B4recognizes Sulfatase 2, showing no cross-reactivity with Sulfatase 1 in either human or mouse.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human Sulfatase 2 (C-Terminal) Antibody, clone 2B4 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD12714
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