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>   home   >   Products   >   Primary Antibodies   >   Anti Human N-Cadherin Antibody, clone 13A9    

Anti Human N-Cadherin Antibody, clone 13A9

Mouse Anti-Human Monoclonal Antibody

     
  • WB - Anti Human N-Cadherin Antibody, clone 13A9  ABD12720
    HT1080 lysate probed with Mouse anti Human N-cadherin followed by Rabbit F(ab')2 anti Mouse IgG:HRP
  • IHC-P - Anti Human N-Cadherin Antibody, clone 13A9  ABD12720
    Formalin fixed, paraffin embedded human breast cancer biopsy stained with Mouse anti Human N-cadherin antibody followed by HRP polymer detection and DAB substrate development following heat mediated antigen retrieval using citrate buffer at pH6.2 (low power)
  • IHC-P - Anti Human N-Cadherin Antibody, clone 13A9  ABD12720
    Formalin fixed, paraffin embedded human breast cancer biopsy stained with Mouse anti Human N-cadherin antibody followed by HRP polymer detection and DAB substrate development following heat mediated antigen retrieval using citrate buffer at pH6.2 (high power)
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IHC-F, IF, IP
Primary Accession Q9Z1Y3
Other Accession P19022
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 13A9
Calculated MW 99686 Da
Additional Information
Other Species Rat
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Recombinant MBP fusion protein containing the entire cytoplasmic domain of human N-cadherin.
Shelf Life 18 months from date of despatch.
Gene ID 83501
Other Names Cadherin-2, Neural cadherin, N-cadherin, CD325, Cdh2
Target/Specificity Mouse anti Human N-cadherin antibody, clone 13A9 specifically recognizes neural cadherin, otherwise known as CD325, a calcium dependent cell-cell adhesion glycoprotein, and member of the cadherin superfamily, which links to the actin cytoskeleton via catenins, and plays a role in cell-matrix adhesion, cell growth and differentiation, and the establishment of left-right asymmetry.N-cadherin is expressed by neurons, endothelial cells, muscle cells, and stem cells, and is one of the primary cadherins recruited to the site of neuronal synapse formation. N-cadherin is directly involved in the differentiation of early hematopoietic progenitors, and is commonly expressed by cancer cells, playing a role in transendothelial migration and metastasis, through the up-regulation of the src kinase pathway, and subsequent failure of the intercellular connection between two adjacent endothelial cells. Mouse anti Human N-cadherin antibody, clone 13A9 studies  have demonstrated that expression levels of E-Cadherin and N-Cadherin have a role to play in the invasive properties of breast cancer. Decreased levels of E-cadherin and loss of E-cadherin-mediated adhesion, can result in the transition of a benign epithelial tumor to an invasive tumor, and increase invasiveness, whilst the expression of N-cadherin correlates with motility, invasiveness and tumor metastasis, irrespective of the presence of E-cadherin (Niemanet al.1999).Mouse anti Human N-cadherin antibody, clone 13A9 has been shown to be specific for N-cadherin, and does not recognize E-cadherin, M-cadherin or P-cadherin (Knudsenet al.1995). Immunohistological studies have shown that clone 13A9 can be used as a reliable marker for the differential diagnosis of pleural mesotheliomas and lung adenocarcinomas, when used in conjunction with E-cadherin (Hanet al.1997).
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human N-Cadherin Antibody, clone 13A9 is for research use only and not for use in diagnostic or therapeutic procedures.
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Cat# ABD12720
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