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>   home   >   Products   >   Primary Antibodies   >   Anti Mouse Notch 2 Antibody, clone HMN2-35    

Anti Mouse Notch 2 Antibody, clone HMN2-35

Hamster Anti-Mouse Monoclonal Antibody

     
  • FC - Anti Mouse Notch 2 Antibody, clone HMN2-35  ABD12723
    Mouse Notch 2 transfected cells stained with Hamster anti Mouse Notch 2
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC
Primary Accession Q9QW30
Other Accession O35516
Reactivity Mouse
Host Hamster
Clonality Monoclonal
Isotype IgG
Clone Names HMN2-35
Calculated MW 265370 Da
Additional Information
Other Species Rat
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Mouse Notch 2-Fc fusion protein.
Shelf Life 18 months from date of despatch.
Other Names Neurogenic locus notch homolog protein 2, Notch 2, Notch 2 extracellular truncation, Notch 2 intracellular domain, Notch2
Target/Specificity Hamster anti Mouse Notch 2 antibody, clone HMN2-35 specifically recognizes Notch 2, one of the four major transmembrane receptors (Notch 1-4) of the Notch signaling pathway, which is activated through binding to DSL domain-containing membrane-bound specific ligands. The Notch signaling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell hematopoiesis, thymic T-cell development, and both tumor progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta-like protein 1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and the gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signaling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. Signaling through Notch 2 has been implicated in the development of marginal zone B cells (MZB), the sensitization of endothelial cells to apoptosis, and the regulation of the expression of CD23 in B-cell lymphocytic leukemia (B-CLL). Studies have also shown a correlation between a decrease in Notch 2 expression and an increase in grade of human breast cancer. Hamster anti Mouse Notch 2 antibody, clone HMN2-35 has been shown to cross-react with rat mast cell line RBL-2H3 and Y3 myeloma cells, in flow cytometry.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Mouse Notch 2 Antibody, clone HMN2-35 is for research use only and not for use in diagnostic or therapeutic procedures.
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Cat# ABD12723
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